

Reprogramming immune cells,
directly inside the patient.
Blue Marlin Therapeutics
is developing a non-viral, in vivo immune-cell engineering platform designed to deliver durable, cell-specific therapies across oncology and autoimmune disease.


Blue Marlin Therapeutics
is developing a non-viral, in vivo immune-cell engineering platform designed to deliver durable, cell-specific therapies across oncology and autoimmune disease.


OUR SCIENCE
A platform for precise immune-cell engineering
Blue Marlin's platform combines antibody-targeted LNP delivery, non-viral integration, and promoter-gated expression to enable precise immune-cell engineering in vivo.

OUR SCIENCE
A platform for precise immune-cell engineering
Blue Marlin's platform combines antibody-targeted LNP delivery, non-viral integration, and promoter-gated expression to enable precise immune-cell engineering in vivo.
TARGETING & DELIVERY
Data-driven LNP optimization
The delivery platform combines proprietary wet-lab data, automated public-data ingestion, and machine-learning models to accelerate LNP discovery. Each design cycle generates formulation, expression, and toxicology data, which feeds back into the model to improve candidate selection. This iterative build-test-learn system helps prioritize the most promising lipids and formulations, enabling faster optimization of targeted in vivo delivery for Blue Marlin’s immune-cell engineering platform.
The delivery platform combines proprietary wet-lab data, automated public-data ingestion, and machine-learning models to accelerate LNP discovery. Each design cycle generates formulation, expression, and toxicology data, which feeds back into the model to improve candidate selection. This iterative build-test-learn system helps prioritize the most promising lipids and formulations, enabling faster optimization of targeted in vivo delivery for Blue Marlin’s immune-cell engineering platform.




DURABLE PROGRAMMING
Non-viral genomic integration
Blue Marlin's platform is designed to support durable immune-cell programming without viral vectors or nuclease-mediated double-strand breaks.
Once delivered, the genetic payload is intended to enable stable expression of therapeutic programs inside selected immune-cell populations.
This approach is designed to combine the persistence of genomic programming with the scalability and flexibility of non-viral delivery.

DURABLE PROGRAMMING
Non-viral genomic integration
Blue Marlin's platform is designed to support durable immune-cell orogramming without viral vectors or nuclease-mediated double-strand breaks. Once delivered, the genetic payload is intended to enable stable expression of therapeutic programs inside selected immune-cell populations. This approach is designed to combine the persistence of genomic programming with the scalability and flexibility of non-viral delivery.
CELL-SPECIFIC CONTROL
Programming
activity in the right
immune cell
Blue Marlin’s platform is designed to add specificity beyond delivery by restricting therapeutic activity to selected immune-cell states. Once payloads reach the target cell population, programmable control elements help ensure the therapeutic program turns on only where it is needed.
This added control layer enables the same platform to support immune activation in oncology or immune regulation in autoimmunity.

CELL-SPECIFIC CONTROL
Programming
activity in the right
immune cell
Blue Marlin’s platform is designed to add specificity beyond delivery by restricting therapeutic activity to selected immune-cell states. Once payloads reach the target cell population, programmable control elements help ensure the therapeutic program turns on only where it is needed.
This added control layer enables the same platform to support immune activation in oncology or immune regulation in autoimmunity.

Our Pipeline








