Reprogramming immune cells,

directly inside the patient.

Blue Marlin Therapeutics

is developing a non-viral, in vivo immune-cell engineering platform designed to deliver durable, cell-specific therapies across oncology and autoimmune disease.

A mockup of Freelio's mobile app
A mockup of Freelio's mobile app

Blue Marlin Therapeutics

is developing a non-viral, in vivo immune-cell engineering platform designed to deliver durable, cell-specific therapies across oncology and autoimmune disease.

A mockup of Freelio's mobile app
An image of Freelio's project ui
OUR SCIENCE

A platform for precise immune-cell engineering

Blue Marlin's platform combines antibody-targeted LNP delivery, non-viral integration, and promoter-gated expression to enable precise immune-cell engineering in vivo.

An image of Freelio's project ui
OUR SCIENCE

A platform for precise immune-cell engineering

Blue Marlin's platform combines antibody-targeted LNP delivery, non-viral integration, and promoter-gated expression to enable precise immune-cell engineering in vivo.

TARGETING & DELIVERY

Data-driven LNP optimization

The delivery platform combines proprietary wet-lab data, automated public-data ingestion, and machine-learning models to accelerate LNP discovery. Each design cycle generates formulation, expression, and toxicology data, which feeds back into the model to improve candidate selection. This iterative build-test-learn system helps prioritize the most promising lipids and formulations, enabling faster optimization of targeted in vivo delivery for Blue Marlin’s immune-cell engineering platform.

The delivery platform combines proprietary wet-lab data, automated public-data ingestion, and machine-learning models to accelerate LNP discovery. Each design cycle generates formulation, expression, and toxicology data, which feeds back into the model to improve candidate selection. This iterative build-test-learn system helps prioritize the most promising lipids and formulations, enabling faster optimization of targeted in vivo delivery for Blue Marlin’s immune-cell engineering platform.

An image of Freelio's budget ui
An image of Freelio's budget ui
An image of Freelio's budget ui
DURABLE PROGRAMMING

Non-viral genomic integration

Blue Marlin's platform is designed to support durable immune-cell programming without viral vectors or nuclease-mediated double-strand breaks.

Once delivered, the genetic payload is intended to enable stable expression of therapeutic programs inside selected immune-cell populations.

This approach is designed to combine the persistence of genomic programming with the scalability and flexibility of non-viral delivery.

DURABLE PROGRAMMING

Non-viral genomic integration

Blue Marlin's platform is designed to support durable immune-cell orogramming without viral vectors or nuclease-mediated double-strand breaks. Once delivered, the genetic payload is intended to enable stable expression of therapeutic programs inside selected immune-cell populations. This approach is designed to combine the persistence of genomic programming with the scalability and flexibility of non-viral delivery.

CELL-SPECIFIC CONTROL

Programming
activity in the right
immune cell

Blue Marlin’s platform is designed to add specificity beyond delivery by restricting therapeutic activity to selected immune-cell states. Once payloads reach the target cell population, programmable control elements help ensure the therapeutic program turns on only where it is needed.

This added control layer enables the same platform to support immune activation in oncology or immune regulation in autoimmunity.

CELL-SPECIFIC CONTROL

Programming
activity in the right
immune cell

Blue Marlin’s platform is designed to add specificity beyond delivery by restricting therapeutic activity to selected immune-cell states. Once payloads reach the target cell population, programmable control elements help ensure the therapeutic program turns on only where it is needed.

This added control layer enables the same platform to support immune activation in oncology or immune regulation in autoimmunity.

Our Pipeline

An image of Freelio's budget ui

Sean Stalfort
CEO & Founder

Oleg Iartchouk
Head of Research

& Co-founder

Joseph Senn
Chief Development and Science Officer & Co-founder

Francisco Navarro
Executive Director

of Cell Therapy

and Research

Justin Powers
Head of Business Development